Understanding how AMPK regulates blood vessel health through ACE2
Illuminating ER Lumen AMPK Dynamics for Maintaining Vascular Homeostasis via ACE2
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10996021
This study is looking at how a protein called AMPK helps keep your blood vessels healthy by working with another protein that helps control blood pressure, and it aims to find new ways to improve treatments for blood pressure issues.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10996021 on ClinicalTrials.gov |
What this research studies
This research investigates the role of adenosine monophosphate-activated kinase (AMPK) in maintaining blood vessel health by interacting with ACE2, a key protein involved in blood pressure regulation. The study will utilize advanced fluorescent biosensors to monitor AMPK activity within the endoplasmic reticulum (ER) and explore the molecular mechanisms that govern this interaction. By examining how AMPK functions in the ER lumen, the research aims to uncover new insights into its role in vascular homeostasis, which could lead to improved treatments for blood pressure-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may be experiencing issues related to blood pressure regulation.
Not a fit: Patients who are under 21 years old or do not have any blood pressure-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing blood pressure and improving vascular health.
How similar studies have performed: Previous research has shown promising results in understanding AMPK's role in metabolic regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LYONS, ANNE — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: LYONS, ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.