Understanding how AMPK affects DNA changes in lung cancer
Official title: Decoding AMPK-dependent regulation of DNA methylation in lung cancer
Funded at Salk Institute for Biological Studies · NIH-11098458 · Data updated 2026-11-12
This study is looking at how a protein called AMPK affects changes in DNA that can help lung cancer grow, especially in tumors with a specific mutation, to find new ways to treat the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | May 19, 2023 |
| Project end | August 18, 2025 |
| Funding year | 2025 |
| Award (this year) | $23,156 |
| NIH project number | 5F32CA275206-03 |
| Project ID | NIH-11098458 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung cancer, particularly those with KRAS mutations.
✕Less likely to help
Patients with lung cancer not driven by KRAS mutations or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates the role of AMP-activated protein kinase (AMPK) in regulating DNA methylation in lung cancer, particularly in tumors driven by mutant KRAS. By exploring how AMPK influences metabolic adaptations and DNA modifications, the study aims to uncover new vulnerabilities in lung cancer cells that could be targeted for treatment. The researchers will utilize advanced techniques such as bisulfite sequencing to analyze DNA methylation patterns and their impact on tumor growth. This work could lead to a better understanding of lung cancer progression and potential new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve survival rates for lung cancer patients.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Yomtoubian, Shira — Salk Institute for Biological Studies
- Study coordinator: Yomtoubian, Shira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.