Understanding how AMPA receptors work in glioblastoma
Characterization of native AMPA receptor structure and function in glioblastoma
This study is looking at how certain brain cell receptors, called AMPA receptors, work in glioblastoma, an aggressive brain cancer, to help find new ways to treat patients by blocking these receptors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11032729 on NIH RePORTER |
What this research studies
This research investigates the structure and function of AMPA receptors in glioblastoma, a type of aggressive brain cancer. By examining the molecular interactions and mechanisms of these receptors, the study aims to uncover how they contribute to cancer progression. The approach involves advanced techniques such as cryo-electron microscopy to visualize the receptors at a high resolution. This knowledge could lead to the development of targeted therapies that inhibit these receptors and improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target AMPA receptors in glioblastoma, potentially improving survival rates.
How similar studies have performed: Other research has shown promising results in targeting similar molecular pathways in cancer treatment, indicating potential for success in this area.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Spangler, Catherine Jeanette — Oregon Health & Science University
- Study coordinator: Spangler, Catherine Jeanette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.