Understanding how amino acid transport proteins form clusters in cell membranes
Official title: Determinants of amino acid transporter oligomerization in membranes
Funded at Washington University · NIH-10725968 · Data updated 2026-11-12
This study is looking at how certain proteins that help move nutrients and brain chemicals in our cells work together and form different shapes, which could help us find better treatments for conditions related to amino acid transport.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $155,500 |
| NIH project number | 1R03NS133680-01 |
| Project ID | NIH-10725968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect amino acid transport, such as certain metabolic disorders or neurological diseases.
✕Less likely to help
Patients with unrelated health issues or those not affected by amino acid transport disorders may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms behind the clustering of amino acid transport proteins in cell membranes, which are crucial for transporting nutrients and neurotransmitters in the body. By examining specific transporters, the study aims to uncover how these proteins interact and form different structures, which may affect their function. The research employs advanced techniques to analyze the stability and interactions of these proteins in various membrane environments. Patients may benefit from insights into how these transporters operate, potentially leading to improved treatments for conditions related to amino acid transport.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of disorders related to amino acid transport, impacting conditions like neurological disorders and kidney function.
How similar studies have gone: Previous research has shown promising results in understanding protein interactions and transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Robertson, Janice L — Washington University
- Study coordinator: Robertson, Janice L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.