Understanding how amino acid availability affects T-cell function in tumors
Official title: Identifying and Targeting Drivers of Impaired Translation in Tumor-infiltrating CD8+ T-cells.
Funded at Sloan-Kettering Inst Can Research · NIH-10990117 · Data updated 2026-11-12
This study is looking at how certain nutrients called amino acids affect immune cells that fight cancer, to help understand why some of these cells get tired and stop working well, which could lead to better treatments for patients with cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $50,474 |
| NIH project number | 1F99CA294267-01 |
| Project ID | NIH-10990117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients whose tumors are resistant to current immunotherapy treatments.
✕Less likely to help
Patients with tumors that respond well to existing immunotherapies may not benefit from this research.
What this research studies
This research investigates the role of amino acids in the function of CD8+ T-cells that infiltrate tumors. It aims to understand why some T-cells become exhausted and lose their ability to fight cancer effectively, particularly in certain tumor types. By examining how amino acid deprivation impacts T-cell activity, the study seeks to uncover mechanisms that could enhance the effectiveness of immune checkpoint blockade therapies. Patients may benefit from insights that could lead to improved cancer treatments targeting T-cell dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the effectiveness of cancer immunotherapies.
How similar studies have gone: Other research has shown promise in understanding T-cell exhaustion and amino acid metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Chen, Yan-Ting — Sloan-Kettering Inst Can Research
- Study coordinator: Chen, Yan-Ting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.