Understanding how Alzheimer's progresses using genetics and brain scans
Characterizing the progression of Alzheimer's disease with multi-omic genetic and imaging data
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11193444
This project uses genetic, molecular, and brain-imaging data to find markers that show how Alzheimer's changes over time for people with Alzheimer's or mild cognitive problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11193444 on ClinicalTrials.gov |
What this research studies
If you take part, researchers will combine your genetic and molecular information with MRI and PET brain scans from large Alzheimer's studies to look for markers that change as the disease progresses. They will analyze DNA, RNA, and protein signals and link those signals to imaging and clinical symptoms using advanced computational methods. The work relies on existing datasets from consortia such as ADNI and AMP-AD rather than testing a new drug. The goal is to group people by likely progression paths to help guide earlier diagnosis and future trial matching.
Who could benefit from this research
Good fit: Ideal candidates are people with Alzheimer's disease, mild cognitive impairment, or older adults enrolled in memory-research cohorts who can provide genetic samples and brain imaging data.
Not a fit: People without genetic or imaging data, or those whose symptoms stem from non‑Alzheimer causes, may not see direct benefit from this work.
Why it matters
Potential benefit: If successful, this could enable earlier detection of progression patterns and better matching of patients to clinical trials or targeted treatments.
How similar studies have performed: Large efforts like ADNI and AMP-AD have found useful biomarkers, but combining multi-omic and imaging data to predict individual progression is still relatively new and not yet fully proven.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAN, JINGWEN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: YAN, JINGWEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease biological marker, Alzheimer's disease patient