Understanding how Alzheimer's disease risk differs between men and women
Elucidating sex-specific risk for Alzheimer's disease through state-of-the-art genetics and multi-omics
This study is looking at how genes and other factors that might increase the risk of Alzheimer's disease can differ between men and women, with the goal of finding better ways to treat and support those at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11017738 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular factors that contribute to Alzheimer's disease (AD) risk, focusing specifically on differences between sexes. By utilizing advanced genetic techniques and big data, the study aims to identify sex-specific risk factors and potential drug targets for AD. The approach includes analyzing large datasets to improve upon previous studies that did not adequately account for these differences. This could lead to more personalized treatment options for individuals at risk of AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry the APOE ε4 allele, particularly focusing on both men and women.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or those who are not interested in genetic research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that are more effective for both men and women at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown that understanding sex differences in diseases can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Belloy, Michael — Washington University
- Study coordinator: Belloy, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.