Understanding how Alzheimer's disease progresses using genetic and imaging data
Official title: Characterizing the progression of Alzheimer's disease with multi-omic genetic and imaging data
Funded at Indiana University Indianapolis · NIH-10802970 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease changes over time by examining genes and brain scans, with the goal of finding clues that can help doctors spot the disease earlier and tailor treatments for people at different stages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 30, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $399,345 |
| NIH project number | 1R01AG081951-01A1 |
| Project ID | NIH-10802970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease or those in the early stages of the condition.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any genetic predisposition to the condition may not benefit from this research.
What this research studies
This research investigates the progression of Alzheimer's disease (AD) by analyzing genetic and brain imaging data. It aims to identify specific genetic biomarkers that can indicate different stages of AD and help differentiate between various clinical trajectories. By utilizing advanced computational methods and existing multi-omic datasets, the study seeks to enhance early diagnosis and improve patient stratification for clinical trials. This could lead to more targeted therapeutic interventions for individuals at risk of developing AD.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more personalized treatment options for patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using multi-omic approaches to understand Alzheimer's disease, suggesting that this methodology could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Yan, Jingwen — Indiana University Indianapolis
- Study coordinator: Yan, Jingwen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.