Understanding how Alzheimer's disease progresses using brain scans
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkers
['FUNDING_R37'] · MAYO CLINIC ROCHESTER · NIH-11085294
This research helps us understand the step-by-step changes in the brain that lead to Alzheimer's disease symptoms in older adults.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11085294 on ClinicalTrials.gov |
What this research studies
We are working to understand the sequence of changes that happen in the brain as Alzheimer's disease develops. Our approach uses a model that suggests amyloid protein buildup comes first, followed by tau protein changes, then brain cell damage, and finally, memory and thinking problems. We use advanced brain scans to look for these amyloid and tau proteins, as well as signs of brain cell damage. This helps us see how these changes unfold over time in people as they age.
Who could benefit from this research
Good fit: This research is focused on understanding Alzheimer's disease progression in the general aging population, including individuals with and without current symptoms.
Not a fit: Patients who are not interested in contributing to the understanding of disease progression through imaging may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection of Alzheimer's disease and help develop treatments that target the disease at its earliest stages.
How similar studies have performed: This work builds upon a long-standing model of Alzheimer's progression, now incorporating newly available tau imaging techniques to further test and refine these ideas.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACK, CLIFFORD R. — MAYO CLINIC ROCHESTER
- Study coordinator: JACK, CLIFFORD R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's Disease Pathway