Understanding how Alzheimer's disease progresses in the aging brain
Mechanisms of Alzheimer's Disease Progression in the Aging Brain
This study is looking at how a protein called tau affects memory and thinking in older adults, helping to tell the difference between normal aging and the early signs of Alzheimer's disease, and it involves nearly 200 healthy older people who will have some brain scans and memory tests over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10651703 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the progression of Alzheimer's disease (AD) in older adults, focusing on the role of tau protein accumulation in the brain. It examines how tau spreads from specific brain regions associated with memory, potentially leading to cognitive decline. The study involves a cohort of nearly 200 cognitively healthy older individuals who will undergo various imaging techniques and cognitive assessments to track changes over time. By understanding these processes, the research aims to differentiate between normal aging and the onset of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are cognitively normal older adults who are at risk for Alzheimer's disease due to age.
Not a fit: Patients with advanced Alzheimer's disease or significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better understanding of Alzheimer's disease, potentially improving treatment strategies.
How similar studies have performed: Other research has shown promising results in understanding tau protein's role in Alzheimer's disease, indicating that this approach is building on established findings.
Where this research is happening
Berkeley, United States
- University of Calif-Lawrenc Berkeley Lab — Berkeley, United States (Active)
Researchers
- Principal investigator: Jagust, William J. — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Jagust, William J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.