Understanding how Alzheimer's disease progresses in sexual and gender minorities
Official title: Disparities of Alzheimer's disease progression in sexual and gender minorities
Funded at University of Florida · NIH-11015768 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects sexual and gender minorities differently, aiming to find out what makes them more at risk and how to better support their health needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $689,054 |
| NIH project number | 5R01AG080624-03 |
| Project ID | NIH-11015768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are sexual and gender minorities who are at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients who do not identify as sexual or gender minorities may not receive direct benefits from this research.
What this research studies
This research investigates the unique health challenges faced by sexual and gender minorities (SGM) in relation to Alzheimer's disease (AD) and related dementias. It aims to identify the different pathways of AD progression and the associated risk factors specific to SGM individuals. By utilizing real-world data from clinical research networks, the study seeks to develop better risk stratification and prevention strategies tailored to this population. The research will also address methodological gaps in understanding how social determinants of health impact AD in SGM.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and care strategies for Alzheimer's disease specifically designed for sexual and gender minorities.
How similar studies have gone: While research on Alzheimer's disease in sexual and gender minorities is limited, the use of real-world data to understand health disparities has shown promise in other areas.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Guo, Yi — University of Florida
- Study coordinator: Guo, Yi
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.