Understanding how Alzheimer's disease affects the aging brain in three dimensions
Official title: Defining the effect of Alzheimer pathologies on the aged brain in 3 dimensions
Funded at Columbia University Health Sciences · NIH-10935932 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects the aging brain by creating a detailed 3D model, helping us understand the changes that lead to memory and thinking problems in older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $6,328,789 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935932 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are experiencing cognitive decline or have a family history of Alzheimer's disease.
✕Less likely to help
Patients with early-stage Alzheimer's disease or those with significant existing neuropathological burdens may not benefit from this research.
What this research studies
This research aims to explore the complex relationship between Alzheimer's disease and cognitive decline in older adults by creating a comprehensive 3D model of the aging brain. It will analyze how various Alzheimer-related proteins and aging impact brain structure and function, using advanced techniques to gather detailed data from diverse individuals. By examining specific brain regions, the study seeks to identify the molecular and cellular changes that contribute to cognitive decline, ultimately enhancing our understanding of Alzheimer's pathology.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or mitigating cognitive decline in individuals at risk for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in understanding Alzheimer's pathology through advanced imaging and molecular analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: De Jager, Philip L — Columbia University Health Sciences
- Study coordinator: De Jager, Philip L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.