Understanding how Alzheimer's disease affects brain circuits involved in cognitive control
Dysregulated frontal-sensory network and cognitive control by Alzheimer's disease pathology
This study looks at how changes in the brain related to Alzheimer's disease affect important connections that help with thinking and decision-making, using special mice to learn more about these issues and find ways to support people with Alzheimer's in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10905428 on NIH RePORTER |
What this research studies
This research investigates the relationship between Alzheimer's disease (AD) pathology and the neural circuits in the frontal cortex that are crucial for cognitive control. It focuses on how the accumulation of amyloid-β (Aβ) impacts the connectivity of these circuits, which may lead to cognitive decline. By studying genetically modified mice that mimic human AD pathology, the research aims to identify vulnerable cognitive networks and understand how disruptions in these circuits contribute to cognitive deficits. The findings could help develop strategies to mitigate cognitive impairments in individuals with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other types of dementia or cognitive impairments unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that improve cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the effects of amyloid pathology on cognitive functions, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Morishita, Hirofumi — Icahn School of Medicine at Mount Sinai
- Study coordinator: Morishita, Hirofumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.