Understanding how Alzheimer's disease affects brain circuits involved in cognitive control

Who could benefit from this research

What this research studies

This research investigates the relationship between Alzheimer's disease (AD) pathology and the neural circuits in the frontal cortex that are crucial for cognitive control. It focuses on how the accumulation of amyloid-β (Aβ) impacts the connectivity of these circuits, which may lead to cognitive decline. By studying genetically modified mice that mimic human AD pathology, the research aims to identify vulnerable cognitive networks and understand how disruptions in these circuits contribute to cognitive deficits. The findings could help develop strategies to mitigate cognitive impairments in individuals with Alzheimer's disease.

Why it matters

Where this research is happening

• Icahn School of Medicine at Mount Sinai
  New York, United States Active

Researchers

• Principal investigator: Morishita, Hirofumi — Icahn School of Medicine at Mount Sinai
• Study coordinator: Morishita, Hirofumi

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.