Understanding how alternative splicing affects protein interactions
Official title: Predicting the functional impact of alternative splicing on protein-protein interactions using an integrated approach
Funded at Worcester Polytechnic Institute · NIH-11037896 · Data updated 2026-11-12
This study is looking at how different versions of proteins, created by a process called alternative splicing, work in our bodies, which could help us understand their role in health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Worcester Polytechnic Institute NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | May 16, 2022 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $289,263 |
| NIH project number | 5R01LM014017-04 |
| Project ID | NIH-11037896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases where alternative splicing plays a significant role.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or alternative splicing may not benefit from this research.
What this research studies
This research investigates the role of alternative splicing in gene expression and its impact on protein interactions. By developing new computational and experimental methods, the project aims to predict how different isoforms of proteins, generated through alternative splicing, function in biological processes. The approach combines advanced bioinformatics with laboratory assays to better understand the complexities of protein behavior in health and disease. This could lead to insights into how these mechanisms contribute to various medical conditions.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and lead to new therapeutic strategies for diseases linked to alternative splicing.
How similar studies have gone: While the approach is innovative, there have been previous studies exploring alternative splicing, but this specific integrated methodology is relatively novel.
Where this research is happening
-
Worcester Polytechnic Institute
Worcester, United States Active
Researchers
- Principal investigator: Korkin, Dmitry — Worcester Polytechnic Institute
- Study coordinator: Korkin, Dmitry
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.