Understanding how alternative splicing affects protein interactions
Predicting the functional impact of alternative splicing on protein-protein interactions using an integrated approach
['FUNDING_R01'] · WORCESTER POLYTECHNIC INSTITUTE · NIH-11037896
This study is looking at how different versions of proteins, created by a process called alternative splicing, work in our bodies, which could help us understand their role in health and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WORCESTER POLYTECHNIC INSTITUTE (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11037896 on ClinicalTrials.gov |
What this research studies
This research investigates the role of alternative splicing in gene expression and its impact on protein interactions. By developing new computational and experimental methods, the project aims to predict how different isoforms of proteins, generated through alternative splicing, function in biological processes. The approach combines advanced bioinformatics with laboratory assays to better understand the complexities of protein behavior in health and disease. This could lead to insights into how these mechanisms contribute to various medical conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases where alternative splicing plays a significant role.
Not a fit: Patients with conditions unrelated to genetic regulation or alternative splicing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and lead to new therapeutic strategies for diseases linked to alternative splicing.
How similar studies have performed: While the approach is innovative, there have been previous studies exploring alternative splicing, but this specific integrated methodology is relatively novel.
Where this research is happening
WORCESTER, UNITED STATES
- WORCESTER POLYTECHNIC INSTITUTE — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KORKIN, DMITRY — WORCESTER POLYTECHNIC INSTITUTE
- Study coordinator: KORKIN, DMITRY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer cell line