Understanding how alternative splicing affects gene expression and disease
Regulation and impact of alternative splicing in biology and disease
This study is looking into how the process that helps our genes work properly can go wrong and cause health issues like genetic diseases and cancer, with the hope of finding better ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10871911 on NIH RePORTER |
What this research studies
This research investigates the process of pre-mRNA splicing, which is essential for the expression of most genes in humans. It focuses on how defects in splicing can lead to genetic diseases and contribute to various cancers. By using advanced techniques such as tissue culture models and bioinformatics, the research aims to uncover the molecular mechanisms that regulate splicing and how these processes can be influenced by specific proteins. The goal is to provide insights that could lead to better understanding and treatment of diseases linked to splicing errors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders or cancers associated with splicing mutations.
Not a fit: Patients with conditions unrelated to splicing defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for genetic diseases and cancers caused by splicing defects.
How similar studies have performed: Previous research has shown promising results in understanding splicing mechanisms, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Hertel, Klemens J — University of California-Irvine
- Study coordinator: Hertel, Klemens J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.