Understanding how alphaviruses translate their RNA
Elucidating the mechanisms of alphavirus subgenomic RNA translation
['FUNDING_FELLOWSHIP'] · ROCKEFELLER UNIVERSITY · NIH-11056802
This study is looking at how certain viruses spread by insects can still make copies of themselves even when your body's defenses are trying to fight them off, and it hopes to find new ways to create treatments for infections caused by these viruses.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11056802 on ClinicalTrials.gov |
What this research studies
This research investigates the unique mechanisms by which alphaviruses, which are transmitted by insects, manage to translate their RNA into proteins even when the host's immune response is activated. The study focuses on the viral subgenomic RNA and how it bypasses the host's defenses to ensure viral replication. By exploring these processes, the research aims to identify potential targets for antiviral treatments that could effectively combat alphavirus infections. This could lead to the development of new therapies for diseases caused by these viruses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with alphaviruses or are at risk of infection due to exposure to arthropod vectors.
Not a fit: Patients who are not affected by alphavirus infections or those who do not have a history of exposure to these viruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral treatments for alphavirus infections, potentially reducing the incidence and severity of related diseases.
How similar studies have performed: Previous research has shown success in developing antiviral treatments targeting viral replication processes, particularly during the COVID-19 pandemic, indicating that similar approaches may be effective for alphaviruses.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DINNON, KENNETH HAROLD — ROCKEFELLER UNIVERSITY
- Study coordinator: DINNON, KENNETH HAROLD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alphavirus Infections