Understanding how alphaviruses invade the brain
Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10903622
This study is looking at how certain viruses, like chikungunya, can get into the brain and cause serious problems, and it's for anyone interested in finding new ways to prevent or treat these infections.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10903622 on ClinicalTrials.gov |
What this research studies
This research investigates how certain viruses, specifically alphaviruses like chikungunya, can cross the blood-brain barrier and cause serious neurological diseases. Using a model created from stem cells, researchers will explore the interactions between the virus and specific cells in the brain that protect it. By identifying the viral components that facilitate this invasion, the study aims to uncover potential therapeutic targets for preventing or treating infections that lead to brain inflammation and other complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been infected with alphaviruses and are experiencing neurological symptoms or complications.
Not a fit: Patients who have not been infected with alphaviruses or do not exhibit any neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for viral infections that affect the brain, potentially reducing the incidence of severe neurological diseases.
How similar studies have performed: Previous research has shown success in using stem cell models to study viral interactions with the blood-brain barrier, indicating that this approach has potential for uncovering new insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALVAREZ, PABLO — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: ALVAREZ, PABLO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.