Understanding how alphaviruses fuse with host cells
Structural Mechanisms of Alphavirus Membrane Fusion
This study is looking at how certain viruses that can cause serious illnesses like arthritis and brain infections get into our cells, with the hope of finding new ways to stop these viruses and help patients get better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11063228 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which alphaviruses, which can cause serious diseases like arthritis and encephalitis, fuse with host cell membranes. By using advanced imaging techniques and biochemical methods, the team aims to uncover the structural details of the viral proteins involved in this process. The findings could lead to the development of new antiviral therapies, as the research focuses on understanding how these viruses enter cells and how their fusion process can be disrupted. Patients may benefit from new treatments that could prevent or cure infections caused by alphaviruses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by alphavirus infections, particularly those experiencing persistent arthritis or encephalitis.
Not a fit: Patients with infections caused by other types of viruses unrelated to alphaviruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral therapies for alphavirus infections.
How similar studies have performed: Previous research has shown promise in understanding viral fusion mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Zhang, Wei — University of Minnesota
- Study coordinator: Zhang, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.