Understanding how alphavirus proteins function inside cells
Intracellular functions and mechanisms of alphavirus ion channel 6K
['FUNDING_R21'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-10912033
This study is looking at a specific protein from alphaviruses, like the ones that cause chikungunya and Eastern equine encephalitis, to understand how it helps the virus spread, with the hope of finding new ways to create treatments that can help patients feel better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-10912033 on ClinicalTrials.gov |
What this research studies
This research investigates the intracellular mechanisms of alphavirus proteins, particularly focusing on the 6K ion channel protein, which is crucial for the virus's ability to replicate and spread. By examining how this protein contributes to the virus's lifecycle, the research aims to identify new targets for antiviral therapies. The study employs advanced molecular techniques to analyze the virus's assembly and budding processes, which could lead to the development of effective treatments for diseases caused by alphaviruses, such as chikungunya and Eastern equine encephalitis. Patients may benefit from this research as it seeks to uncover potential antiviral strategies that could alleviate the severe symptoms associated with these infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by alphavirus infections, such as those experiencing chikungunya fever or Eastern equine encephalitis.
Not a fit: Patients with infections caused by viruses other than alphaviruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments for alphavirus infections, improving patient outcomes.
How similar studies have performed: Other research has shown promise in targeting viral proteins for antiviral development, suggesting that this approach could be effective.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOSE, JOYCE — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: JOSE, JOYCE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alphavirus Infections