Understanding how alphavirus proteins function inside cells
Official title: Intracellular functions and mechanisms of alphavirus ion channel 6K
Funded at Pennsylvania State University, the · NIH-10912033 · Data updated 2026-11-12
This study is looking at a specific protein from alphaviruses, like the ones that cause chikungunya and Eastern equine encephalitis, to understand how it helps the virus spread, with the hope of finding new ways to create treatments that can help patients feel better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $196,044 |
| NIH project number | 5R21AI178533-02 |
| Project ID | NIH-10912033 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals affected by alphavirus infections, such as those experiencing chikungunya fever or Eastern equine encephalitis.
✕Less likely to help
Patients with infections caused by viruses other than alphaviruses may not receive any benefit from this research.
What this research studies
This research investigates the intracellular mechanisms of alphavirus proteins, particularly focusing on the 6K ion channel protein, which is crucial for the virus's ability to replicate and spread. By examining how this protein contributes to the virus's lifecycle, the research aims to identify new targets for antiviral therapies. The study employs advanced molecular techniques to analyze the virus's assembly and budding processes, which could lead to the development of effective treatments for diseases caused by alphaviruses, such as chikungunya and Eastern equine encephalitis. Patients may benefit from this research as it seeks to uncover potential antiviral strategies that could alleviate the severe symptoms associated with these infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral treatments for alphavirus infections, improving patient outcomes.
How similar studies have gone: Other research has shown promise in targeting viral proteins for antiviral development, suggesting that this approach could be effective.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Jose, Joyce — Pennsylvania State University, the
- Study coordinator: Jose, Joyce
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.