Understanding how alpha-synuclein affects cell membranes in Parkinson's disease
PROVIDE NEW INSIGHTS IN ALPHA-SYNUCLEIN INDUCED CELL MEMBRANE DISRUPTION USING SCANNING ION CONDUCTANCE MICROSCOPY AND SURFACE PLASMON RESONANCE MICROSCOPY
This study is looking at how a protein called alpha-synuclein, which is connected to Parkinson's disease, affects brain cells and how things like tiny plastic particles in the environment might make it worse, all to find new ways to help people with Parkinson's.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10974782 on NIH RePORTER |
What this research studies
This research investigates the role of alpha-synuclein, a protein linked to Parkinson's disease, in disrupting neuronal cell membranes. Using advanced imaging techniques like scanning ion conductance microscopy and surface plasmon resonance microscopy, the study aims to explore how different forms of alpha-synuclein, particularly its phosphorylated variant, impact neuronal health. The research will also examine the effects of environmental toxins, such as nanoplastics, on alpha-synuclein aggregation and its interactions with cell membranes. By deepening our understanding of these mechanisms, the research seeks to identify potential therapeutic targets for Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk due to genetic or environmental factors.
Not a fit: Patients with other neurodegenerative disorders unrelated to alpha-synuclein may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding alpha-synuclein's role in neurodegeneration, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- California State University Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wang, Yixian — California State University Los Angeles
- Study coordinator: Wang, Yixian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.