Understanding how alpha defensins help maintain a healthy balance of gut microbes
Official title: Alpha defensins: innate keepers of host-commensal homeostasis
Funded at University of Chicago · NIH-11129815 · Data updated 2026-11-12
This study is looking at how certain natural proteins in the gut help keep a healthy balance of good bacteria, which could be important for your immune system and overall gut health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 2, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $246,000 |
| NIH project number | 5R21AI186365-02 |
| Project ID | NIH-11129815 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with gastrointestinal disorders or those interested in understanding their gut microbiome.
✕Less likely to help
Patients without any gastrointestinal issues or those not interested in microbiome research may not benefit from this research.
What this research studies
This research investigates the role of alpha defensins, which are antimicrobial peptides, in regulating the balance of beneficial microbes in the gut. By studying the differences in defensin expression in various mouse models, the researchers aim to uncover how these peptides contribute to the host's immune response and microbial community composition. The study will involve analyzing genetic factors that influence defensin levels and their impact on gut health, providing insights into the complex interactions between the immune system and gut microbiota.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing gut health and preventing diseases related to microbial imbalances.
How similar studies have gone: Previous research has shown promising results in understanding the role of antimicrobial peptides in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Chervonsky, Alexander V — University of Chicago
- Study coordinator: Chervonsky, Alexander V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.