Understanding how allostery affects GPCRs and G proteins
Official title: Emergent role of allostery on function of GPCRs and Trimeric G proteins
Funded at Beckman Research Institute/city of Hope · NIH-11011982 · Data updated 2026-11-12
This study is looking at how certain proteins in our body work together and how we can use this information to create better medications, which could help improve treatments for conditions like diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $445,000 |
| NIH project number | 1R35GM156498-01 |
| Project ID | NIH-11011982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with conditions related to GPCR dysfunction, such as diabetes or other metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to GPCRs or those who do not respond to GPCR-targeted therapies may not benefit from this research.
What this research studies
This research investigates the dynamic interactions between G protein-coupled receptors (GPCRs) and G proteins, focusing on how allosteric modulation influences their function. By utilizing advanced computational methods, including AI techniques, the project aims to explore the structural basis of these interactions and their implications for drug action. Patients may benefit from insights gained into how drugs can be designed to target these receptors more effectively, potentially leading to better treatment options for conditions like diabetes.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective drugs targeting GPCRs, improving treatment outcomes for patients with various conditions.
How similar studies have gone: Previous research has shown promise in understanding GPCR dynamics and allosteric modulation, indicating that this approach could yield significant advancements.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Vaidehi, Nagarajan — Beckman Research Institute/city of Hope
- Study coordinator: Vaidehi, Nagarajan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.