Understanding how allergens trigger allergic diseases
Mechanisms of Allergen-induced Type 2 Immunity
This study looks at how breathing in natural allergens can trigger allergies and asthma by affecting certain immune cells, and it hopes to find new ways to help people manage or prevent these conditions.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11075293 on NIH RePORTER |
What this research studies
This research investigates how exposure to natural allergens in the air leads to the development of type 2 immunity and various allergic diseases, including asthma and food allergies. The study focuses on the roles of specific immune cells, such as T follicular helper cells and tissue-resident memory cells, in driving exaggerated immune responses. By examining these mechanisms, the research aims to uncover how different types of immune responses contribute to allergic reactions and inflammation in the airway. Patients may benefit from insights that could lead to new treatments or preventive strategies for allergic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with allergic conditions such as asthma, allergic rhinitis, or food allergies.
Not a fit: Patients with non-allergic respiratory conditions or those without a history of allergic reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for patients suffering from allergic diseases.
How similar studies have performed: Previous research has shown promising results in understanding the immune mechanisms behind allergic diseases, indicating that this approach has potential for success.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Kita, Hirohito — Mayo Clinic Arizona
- Study coordinator: Kita, Hirohito
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.