Understanding how allergens affect immune responses in allergic asthma
Epigenetic Mechanism Reprogramming Mucosal Anti-viral Immunity in Allergic Asthma
['FUNDING_U01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10553704
This study is looking at how colds caused by rhinovirus can make asthma worse for adults with allergic asthma, and it aims to find out how certain proteins and genes affect the immune system's response to these viruses, which could help develop better treatments for asthma.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10553704 on ClinicalTrials.gov |
What this research studies
This research investigates how rhinovirus infections trigger asthma exacerbations in adults with allergic asthma. It focuses on the role of specific proteins and genetic factors that may alter the immune response to viral infections, particularly how allergens can suppress the body's ability to fight off these viruses. By examining the interactions between immune cells and genetic regulators, the study aims to uncover new mechanisms that could lead to improved treatments for asthma patients. The research employs advanced techniques to analyze cellular responses and genetic modifications in lung cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with allergic asthma who experience frequent exacerbations due to viral infections.
Not a fit: Patients without allergic asthma or those whose asthma is not triggered by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response in patients with allergic asthma, reducing the frequency and severity of asthma attacks.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in asthma, but this specific approach focusing on epigenetic mechanisms is relatively novel.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRASIER, ALLAN R. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BRASIER, ALLAN R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.