Understanding how alcohol exposure during pregnancy affects cell growth and development
Cell cycle regulation in Fetal Alcohol Spectrum Disorders
['FUNDING_OTHER'] · UPSTATE MEDICAL UNIVERSITY · NIH-10914310
This study looks at how drinking alcohol during pregnancy can affect the growth of a baby's brain and other organs, using mice to understand the changes that happen in cells, which could help us find better ways to support kids with Fetal Alcohol Spectrum Disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UPSTATE MEDICAL UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-10914310 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of alcohol exposure during a critical period of pregnancy on the development of the fetal brain and other organs. It focuses on how alcohol disrupts the normal cell cycle, which is essential for proper cell growth and division. Using a mouse model, the study examines changes in gene expression and signaling pathways that regulate cell proliferation, aiming to uncover the mechanisms behind the physical and cognitive impairments associated with Fetal Alcohol Spectrum Disorders (FASD). The findings could lead to better understanding and potential interventions for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who were exposed to alcohol in utero and may exhibit symptoms of Fetal Alcohol Spectrum Disorders.
Not a fit: Patients who were not exposed to alcohol during pregnancy or do not exhibit symptoms of Fetal Alcohol Spectrum Disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing or mitigating the effects of Fetal Alcohol Spectrum Disorders in children.
How similar studies have performed: Previous research has shown that understanding cell cycle regulation can lead to significant advancements in addressing developmental disorders, suggesting that this approach has potential for success.
Where this research is happening
SYRACUSE, UNITED STATES
- UPSTATE MEDICAL UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOSCHEN, KAREN ELIZABETH — UPSTATE MEDICAL UNIVERSITY
- Study coordinator: BOSCHEN, KAREN ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.