Understanding how alcohol damages the liver
Mitochondrial depolarization, mitophagy, and mitochondrial DAMPs in ALD
This study is looking at how drinking alcohol can harm your liver and what happens to liver cells, with the goal of finding new ways to help prevent or treat liver problems caused by alcohol.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10893570 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which alcohol consumption leads to liver damage, particularly focusing on mitochondrial function and the body's response to alcohol. It aims to uncover how the liver processes ethanol and the subsequent effects on liver cells, including the development of fibrosis and cirrhosis. By studying the signals and pathways involved in mitochondrial depolarization and mitophagy, the research seeks to identify potential therapeutic strategies to prevent or treat alcohol-associated liver disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who are experiencing liver-related issues, such as fibrosis or cirrhosis.
Not a fit: Patients who do not consume alcohol or have no liver-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for alcohol-associated liver disease, improving outcomes for patients suffering from liver damage.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial dysfunction in liver diseases, suggesting that this approach could yield significant insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Zhong, Zhi — Medical University of South Carolina
- Study coordinator: Zhong, Zhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.