Understanding how alcohol affects the metabolism of vital organs
Official title: Elucidating alcohol-induced metabolic remodeling of critical organs
Funded at University of California-Irvine · NIH-10667050 · Data updated 2026-11-12
This study looks at how drinking alcohol affects the way important organs in pigs process nutrients, which could help us understand how alcohol can harm our health and lead to better treatments for related issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 12, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $412,125 |
| NIH project number | 1R21AA030358-01A1 |
| Project ID | NIH-10667050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume alcohol regularly and may be at risk for alcohol-related health issues.
✕Less likely to help
Patients who do not consume alcohol or have no history of alcohol-related health problems may not benefit from this research.
What this research studies
This research investigates the impact of alcohol consumption on the metabolism of critical organs, aiming to uncover how these changes contribute to organ damage. By using a unique method called arteriovenous metabolomics, the study will measure the dynamic metabolic activities of various organs in pigs that have been fed alcohol. This approach allows researchers to analyze how metabolites are absorbed and released by each organ, providing insights into the metabolic processes affected by alcohol. The findings could lead to a better understanding of alcohol-related health issues and inform potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating alcohol-induced organ damage.
How similar studies have gone: While the specific approach of arteriovenous metabolomics is relatively novel, similar studies have shown promise in understanding metabolic changes in other contexts.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Jang, Cholsoon — University of California-Irvine
- Study coordinator: Jang, Cholsoon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.