Understanding how alcohol affects the metabolism of vital organs
Elucidating alcohol-induced metabolic remodeling of critical organs
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10667050
This study looks at how drinking alcohol affects the way important organs in pigs process nutrients, which could help us understand how alcohol can harm our health and lead to better treatments for related issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10667050 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of alcohol consumption on the metabolism of critical organs, aiming to uncover how these changes contribute to organ damage. By using a unique method called arteriovenous metabolomics, the study will measure the dynamic metabolic activities of various organs in pigs that have been fed alcohol. This approach allows researchers to analyze how metabolites are absorbed and released by each organ, providing insights into the metabolic processes affected by alcohol. The findings could lead to a better understanding of alcohol-related health issues and inform potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who consume alcohol regularly and may be at risk for alcohol-related health issues.
Not a fit: Patients who do not consume alcohol or have no history of alcohol-related health problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating alcohol-induced organ damage.
How similar studies have performed: While the specific approach of arteriovenous metabolomics is relatively novel, similar studies have shown promise in understanding metabolic changes in other contexts.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JANG, CHOLSOON — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: JANG, CHOLSOON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.