Understanding how alcohol affects pancreatic cell health
Novel mechanisms of regulating endoplasmic reticulum homeostasis in alcoholic pancreatitis
['FUNDING_R21'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-10742433
This study looks at how drinking alcohol affects the health of your pancreas and aims to find ways to protect it from damage, which could help prevent problems like pancreatitis.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10742433 on ClinicalTrials.gov |
What this research studies
This research investigates how alcohol consumption impacts the health of pancreatic cells, particularly focusing on the mechanisms that help these cells maintain balance and function despite the stress caused by alcohol. It explores the role of the endoplasmic reticulum (ER) in pancreatic cells and how disruptions in its function can lead to conditions like pancreatitis. The study uses experimental models to observe changes in cell behavior and the protective mechanisms that may prevent damage from alcohol. By understanding these processes, the research aims to identify potential therapeutic targets for preventing alcohol-related pancreatic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who consume alcohol heavily but do not currently have pancreatitis or those who have experienced mild pancreatic issues related to alcohol.
Not a fit: Patients who have already been diagnosed with severe alcoholic pancreatitis or those who do not consume alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating alcoholic pancreatitis, improving outcomes for individuals affected by alcohol use.
How similar studies have performed: Previous research has shown promising results in understanding cellular responses to alcohol, suggesting that this approach could yield valuable insights into alcohol-related pancreatic conditions.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DING, WEN-XING — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: DING, WEN-XING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.