Understanding how alcohol affects liver health through specific cellular signaling
Redox Regulation of O-GlcNAcylation Signaling in the Pathogenesis of Alcoholic Fatty Liver Disease
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11030757
This study is looking into how drinking alcohol can harm the liver and what happens in the body that makes it worse, with the hope of finding new ways to help people with alcoholic fatty liver disease feel better and manage their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11030757 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind alcoholic fatty liver disease (AFLD), a significant cause of chronic liver issues. It focuses on how oxidative stress and specific cellular signaling pathways, particularly O-GlcNAcylation, contribute to liver damage from alcohol consumption. By studying the role of glutathione and its effects on liver metabolism, the research aims to uncover new ways to prevent or treat AFLD. Patients may benefit from insights that could lead to novel therapies or diagnostic tools.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of alcohol consumption who are experiencing liver-related health issues.
Not a fit: Patients with liver diseases unrelated to alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive strategies for patients suffering from alcoholic fatty liver disease.
How similar studies have performed: Previous research has shown promising results in understanding liver diseases related to alcohol, but this specific approach focusing on redox regulation and O-GlcNAcylation is relatively novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YING — YALE UNIVERSITY
- Study coordinator: CHEN, YING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: alcohol induced hepatic injury, alcohol induced liver disorder, alcohol induced liver injury