Understanding how alcohol affects liver cell protection mechanisms
Mechanisms regulating autophagy in alcohol-induced liver injury
This study looks at how drinking alcohol over a long time affects liver cells and their ability to stay healthy, focusing on a special protein that helps protect these cells; the goal is to find new ways to treat liver damage from alcohol, which could help patients like you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11087510 on NIH RePORTER |
What this research studies
This research investigates the effects of alcohol on liver cells, particularly how chronic alcohol consumption impairs protective processes like autophagy, which is crucial for cell health. The study focuses on a specific protein, TFEB, that regulates the production of cellular components that help detoxify and protect liver cells. By exploring the molecular pathways involved, the research aims to identify potential targets for new treatments for alcoholic liver disease. Patients may benefit from insights that could lead to innovative therapies for liver damage caused by alcohol.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use who are experiencing liver-related health issues.
Not a fit: Patients who do not consume alcohol or have liver conditions unrelated to alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from alcoholic liver disease.
How similar studies have performed: Previous research has shown promising results in understanding cellular protective mechanisms in liver disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Ding, Wen-Xing — University of Kansas Medical Center
- Study coordinator: Ding, Wen-Xing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.