Understanding how alcohol affects liver cell function and inflammation
Official title: Mechanisms of mitochondrial dynamics, quality control and mtDNA-mediated inflammation in alcohol-associated liver disease
Funded at University of Kansas Medical Center · NIH-11173761 · Data updated 2026-11-12
This study looks at how drinking alcohol affects liver cells and could lead to new ways to help people with liver problems caused by alcohol, so you can better understand how your drinking might impact your liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 20, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $386,542 |
| NIH project number | 5R01AA031230-02 |
| Project ID | NIH-11173761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with alcohol-associated liver disease or those experiencing liver issues related to alcohol consumption.
✕Less likely to help
Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
What this research studies
This research investigates the effects of alcohol on liver cells, focusing on how alcohol metabolism leads to changes in mitochondrial function and inflammation. The study explores the relationship between alcohol consumption and the formation of large mitochondria, which may play a role in liver disease. By examining these mechanisms, the research aims to uncover potential pathways for developing new treatments for alcohol-associated liver disease. Patients may benefit from insights into how their liver health is affected by alcohol and potential new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for alcohol-associated liver disease, improving patient outcomes.
How similar studies have gone: Previous research has shown that understanding mitochondrial dynamics in liver cells can lead to significant advancements in treating liver diseases, suggesting this approach has potential for success.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Ding, Wen-Xing — University of Kansas Medical Center
- Study coordinator: Ding, Wen-Xing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.