Understanding how alcohol affects brain signaling in a specific brain region
Investigating tonic and synaptic excitatory signaling in the bed nucleus of the stria terminalis across models of alcohol exposure
['FUNDING_FELLOWSHIP'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10931384
This study is looking at how alcohol affects certain brain receptors that might help us understand why some people struggle with alcohol use, and it hopes to find new ways to help those who are dealing with this issue.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10931384 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of alcohol exposure on specific receptors in the brain, particularly focusing on the bed nucleus of the stria terminalis (BNST). It aims to understand how alcohol influences excitatory signaling through delta glutamate receptors, which have not been thoroughly studied in the context of alcohol use disorder. By examining changes in synaptic activity and receptor function, the research seeks to uncover the underlying mechanisms that contribute to alcohol-related brain dysfunction. Patients may benefit from insights gained about how alcohol impacts brain signaling and potentially lead to new treatment approaches for alcohol use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder or those experiencing alcohol-related symptoms.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals struggling with alcohol use disorder.
How similar studies have performed: While the effects of alcohol on glutamatergic signaling have been studied, the specific focus on delta glutamate receptors in this context is relatively novel.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONLEY, SARA YI-LING — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: CONLEY, SARA YI-LING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.