Understanding how alcohol affects brain gene regulation
Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol
This study is looking at how drinking alcohol affects the way our brain genes work, with the goal of finding new ways to help people who struggle with alcohol addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10931720 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between alcohol consumption and the regulation of gene expression in the brain. It focuses on how metabolic processes and epigenetic factors influence neuronal behavior and contribute to alcohol addiction. By examining changes in brain chromatin and the role of metabolic enzymes, the study aims to uncover new therapeutic targets for treating alcohol use disorders. Patients may benefit from insights that could lead to more effective treatments for alcohol dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with alcohol dependence or those who consume alcohol regularly.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that more effectively treat alcohol addiction.
How similar studies have performed: Other research has shown promising results in exploring epigenetic factors in addiction, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Mews, Philipp — Boston University Medical Campus
- Study coordinator: Mews, Philipp
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.