Understanding how alcohol affects brain function and movement
The role of mitochondrial stress response in alcohol-mediated neurotoxicity
This study looks at how drinking too much alcohol can hurt the brain and affect movement, using tiny worms to see how alcohol causes stress in cells and impacts their energy production; the goal is to find ways to help protect against these movement problems caused by alcohol.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project ID | NIH-10708781 on NIH RePORTER |
What this research studies
This research investigates the harmful effects of chronic alcohol consumption on the brain and movement abilities. It uses a model organism, C. elegans, to explore how alcohol induces stress responses in cells, particularly focusing on mitochondrial function. The study aims to identify mechanisms that protect against movement impairments caused by alcohol, specifically through the activation of a cellular stress response in neurons. By understanding these processes, the research seeks to uncover potential therapeutic targets for alcohol-related neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of chronic alcohol use who may be experiencing movement disorders or cognitive impairments.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the brain from damage caused by excessive alcohol consumption.
How similar studies have performed: Previous research has shown that targeting cellular stress responses can mitigate damage in various neurodegenerative conditions, suggesting potential for success in this novel approach.
Where this research is happening
North Chicago, United States
- Rosalind Franklin Univ of Medicine & Sci — North Chicago, United States (Active)
Researchers
- Principal investigator: Kim, Hongkyun — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Kim, Hongkyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.