Understanding how alcohol affects brain cell regulation
Defining the metabolic-epigenetic regulation of neuronal chromatin by alcohol
This study is looking at how a substance from alcohol affects brain cells and could help us understand alcohol addiction better, which might lead to new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11082661 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind alcohol use disorder (AUD), focusing on how alcohol-derived acetate influences brain cell regulation through epigenetic changes. It examines the transport of acetate into the brain and its effects on histone acetylation in neurons and astrocytes. By studying specific transport pathways and their differential expression in brain cells, the research aims to uncover new insights into the biological processes that contribute to alcohol addiction. This could lead to a better understanding of AUD and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with alcohol use disorder, particularly those affected by binge drinking.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for alcohol use disorder, potentially reducing its psychological and economic impacts on individuals and communities.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of alcohol addiction, but this specific approach focusing on acetate transport is relatively novel.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Mews, Philipp — Boston University Medical Campus
- Study coordinator: Mews, Philipp
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.