Understanding how airway cells and immune cells interact in lung transplant complications
Airway epithelial cell and lymphocyte interactions in chronic lung allograft dysfunction pathogenesis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10908582
This study is looking at how certain cells in the lungs interact with immune cells to better understand chronic lung problems that can happen after a transplant, with the hope of finding new ways to help lung transplant patients breathe easier and stay healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10908582 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between airway epithelial cells and lymphocytes to understand the development of chronic lung allograft dysfunction (CLAD), a condition that affects lung transplant recipients. By analyzing gene expression changes in airway samples from patients, the study aims to uncover the mechanisms that lead to fibrosis and loss of lung function post-transplant. The research utilizes advanced techniques such as transcriptional analysis and pathway analysis to explore how hypoxia and immune responses contribute to CLAD. This could provide insights into potential therapeutic targets for improving lung transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation and are experiencing or at risk for chronic lung allograft dysfunction.
Not a fit: Patients who have not received a lung transplant or those with other unrelated lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the long-term survival and quality of life for lung transplant recipients.
How similar studies have performed: Previous research has shown promising results in understanding lung transplant complications through similar gene expression analysis techniques.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREENLAND, JOHN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: GREENLAND, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.