Understanding how air pollution affects heart and metabolic health
Dissecting the Role of Arachidonic Acid Metabolic Pathways Involved in Resolution Versus Progression of PM-Induced Cardiometabolic Toxicity
This study looks at how breathing in dirty air, like from car exhaust, can affect heart health and metabolism, especially for people at risk of heart problems, and aims to find ways to reduce these health risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10997439 on NIH RePORTER |
What this research studies
This research investigates how chronic exposure to air pollution, specifically particulate matter, impacts heart health and metabolism. It focuses on the role of arachidonic acid metabolic pathways and inflammatory responses in the development of conditions like atherosclerosis. By studying the effects of diesel exhaust and ultrafine particles on mice, the research aims to identify the molecular mechanisms that lead to cardiovascular issues and metabolic disorders. Patients may benefit from insights gained about how to mitigate these health risks associated with air pollution.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cardiovascular issues or those living in areas with high levels of air pollution.
Not a fit: Patients who do not have cardiovascular conditions or who live in areas with low air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular diseases linked to air pollution exposure.
How similar studies have performed: Previous studies have shown that air pollution can exacerbate cardiovascular diseases, indicating that this research builds on established findings.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Araujo, Jesus Antonio — University of California Los Angeles
- Study coordinator: Araujo, Jesus Antonio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.