Understanding how aging stem cells can turn into cancer cells
Identification and targeting of pathways separating healthy stem cell aging from malignant transformation
This study is looking at how healthy aging stem cells can change into cancer cells, specifically in conditions like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), to find ways to keep stem cells healthy and potentially prevent these serious diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10889329 on NIH RePORTER |
What this research studies
This research investigates the differences between healthy aging stem cells and those that transform into cancerous cells, specifically focusing on myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The study aims to uncover the mechanisms that lead to these transformations, particularly the role of chaperone-mediated autophagy in maintaining healthy stem cell function during aging. By using advanced genetic mouse models, researchers will explore how these processes can be targeted to develop better treatments for these serious conditions. The findings could provide insights into preventing the progression from precancerous states to full-blown malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals, particularly those aged 65 and older, who are at risk for or diagnosed with myelodysplastic syndrome or acute myeloid leukemia.
Not a fit: Patients who are younger than 21 years old or those without any hematologic malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with MDS and AML.
How similar studies have performed: While the specific approach of targeting chaperone-mediated autophagy in this context is novel, similar research has shown promise in understanding cancer biology and aging.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Will, Britta — Albert Einstein College of Medicine
- Study coordinator: Will, Britta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.