Understanding how aging of the placenta affects heart health in new mothers
Official title: Placental Senescence in Peripartum Cardiomyopathy
Funded at Massachusetts General Hospital · NIH-10875429 · Data updated 2026-11-12
This study is looking at how a rare heart condition called peripartum cardiomyopathy, which can happen during late pregnancy or after childbirth, might be linked to the aging of the placenta, and it aims to find out what causes this condition so that better treatments can be developed for women who experience it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $457,978 |
| NIH project number | 5R01HL170058-02 |
| Project ID | NIH-10875429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who are pregnant or have recently given birth and are experiencing symptoms of heart failure.
✕Less likely to help
Patients who are not pregnant or have not recently given birth are unlikely to benefit from this research.
What this research studies
This research investigates peripartum cardiomyopathy (PPCM), a rare heart failure condition that can occur in women during late pregnancy and shortly after childbirth. The study aims to uncover the underlying biological mechanisms, particularly focusing on how accelerated aging of the placenta may contribute to this condition. By analyzing the proteins present in the blood of affected women, researchers hope to identify harmful factors that trigger heart dysfunction. The ultimate goal is to establish a causal link between placental aging and the onset of PPCM, which could lead to better treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women suffering from peripartum cardiomyopathy.
How similar studies have gone: Previous research has shown promising results in understanding the role of biological aging in various health conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Roh, Jason David — Massachusetts General Hospital
- Study coordinator: Roh, Jason David
Related research
Other NIH-funded projects on the same topics.
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Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
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Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
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Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
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Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.