Understanding how aging of the placenta affects heart health in new mothers
Placental Senescence in Peripartum Cardiomyopathy
This study is looking at how a rare heart condition called peripartum cardiomyopathy, which can happen during late pregnancy or after childbirth, might be linked to the aging of the placenta, and it aims to find out what causes this condition so that better treatments can be developed for women who experience it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10875429 on NIH RePORTER |
What this research studies
This research investigates peripartum cardiomyopathy (PPCM), a rare heart failure condition that can occur in women during late pregnancy and shortly after childbirth. The study aims to uncover the underlying biological mechanisms, particularly focusing on how accelerated aging of the placenta may contribute to this condition. By analyzing the proteins present in the blood of affected women, researchers hope to identify harmful factors that trigger heart dysfunction. The ultimate goal is to establish a causal link between placental aging and the onset of PPCM, which could lead to better treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are pregnant or have recently given birth and are experiencing symptoms of heart failure.
Not a fit: Patients who are not pregnant or have not recently given birth are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for women suffering from peripartum cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding the role of biological aging in various health conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Roh, Jason David — Massachusetts General Hospital
- Study coordinator: Roh, Jason David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.