Understanding how aging immune cells interact with bone cells
Defining the interactions of senescent immune cells and skeletal cells
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11054640
This study is looking at how certain aging immune cells affect bone health, especially in conditions like osteoporosis, to help find new ways to treat these issues as we get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11054640 on ClinicalTrials.gov |
What this research studies
This research investigates the role of senescent immune cells in the aging process, particularly their interactions with skeletal cells that contribute to age-related conditions like osteoporosis. By using advanced mouse models, the researchers aim to identify how these immune cells influence bone health and aging. The study focuses on the mechanisms of cellular senescence and how it affects both immune and bone cells, potentially leading to new insights into age-related bone loss. Patients may benefit from findings that could inform future treatments for osteoporosis and other age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related bone loss or osteoporosis.
Not a fit: Patients with acute bone injuries or those not experiencing age-related bone conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve bone health and reduce the risk of osteoporosis in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding cellular senescence and its impact on aging, suggesting that this approach may yield valuable insights.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHOSLA, SUNDEEP — MAYO CLINIC ROCHESTER
- Study coordinator: KHOSLA, SUNDEEP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.