Understanding how aging fat cells affect brain function and Alzheimer's disease
Investigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease Progression
This study is looking at how aging fat cells might affect brain health and contribute to Alzheimer's disease, with the hope of finding new ways to help people who are dealing with memory problems related to obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11164768 on NIH RePORTER |
What this research studies
This research investigates the role of senescent cells in adipose (fat) tissue and their impact on cognitive function and the progression of Alzheimer's disease. By examining how these aging cells contribute to inflammation and brain dysfunction, the study aims to uncover new insights into the biological mechanisms behind Alzheimer's. The research will utilize animal models to explore the relationship between adipose senescence and cognitive decline, potentially leading to novel therapeutic strategies. Patients may benefit from findings that could inform future treatments targeting obesity-related cognitive impairment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive decline associated with aging or obesity.
Not a fit: Patients with early-stage Alzheimer's disease who do not have obesity or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and slow the progression of Alzheimer's disease in patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of senescent cells in age-related diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Zhu, Yi — Mayo Clinic Rochester
- Study coordinator: Zhu, Yi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.