Understanding how aging cells stop dividing
Official title: Progressive states of cell-cycle withdrawal
Funded at University of Colorado · NIH-11079589 · Data updated 2026-11-12
This study is looking at how aging affects our cells and their ability to heal, especially in older adults, to help improve cancer treatments and other health issues related to getting older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $370,740 |
| NIH project number | 5R01AG082942-03 |
| Project ID | NIH-11079589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing age-related health issues or undergoing cancer treatment.
✕Less likely to help
Patients younger than 65 or those without age-related conditions may not benefit from this research.
What this research studies
This research investigates the process of cellular senescence, where cells stop dividing due to aging or damage, and how this impacts health in older adults. The study aims to differentiate between senescence and quiescence, a temporary resting state, using advanced microscopy and tracking techniques. By examining the markers that indicate these states, the research seeks to uncover how they affect cellular function and regeneration, particularly in the context of cancer treatment. Patients may benefit from insights that could improve therapies targeting aging-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better cancer treatments and improved health outcomes for older adults by enhancing our understanding of cellular aging.
How similar studies have gone: Previous research has shown promise in understanding cellular senescence and its implications for aging and cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Spencer, Sabrina Leigh — University of Colorado
- Study coordinator: Spencer, Sabrina Leigh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.