Understanding how aging cells contribute to inflammation and mitochondrial DNA buildup
Senescent cells drive mt-DNA accumulation and inflamm-aging
This study is looking at how aging cells in our bodies can cause inflammation and affect organ transplants, and it hopes to find ways to use special treatments to help improve the success of transplants from older donors, which could benefit patients needing new organs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10837156 on NIH RePORTER |
What this research studies
This research investigates the role of senescent cells in the aging process and their impact on inflammation and mitochondrial DNA accumulation. By examining how these aging cells affect immune responses, particularly in the context of organ transplantation, the study aims to identify potential therapeutic targets. The researchers will explore the use of senolytics, which are agents that can eliminate senescent cells, to reduce inflammation and improve transplant outcomes. Patients may benefit from insights that could enhance the viability of organs from older donors.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who may require organ transplants or have age-related inflammatory conditions.
Not a fit: Patients who are not elderly or do not have conditions related to aging or organ transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved organ transplant outcomes and better utilization of older donor organs.
How similar studies have performed: Previous research has shown promise in using senolytics to reduce inflammation and improve health outcomes in aging populations, indicating a potential for success in this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Tullius, Stefan Gunther — Brigham and Women's Hospital
- Study coordinator: Tullius, Stefan Gunther
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.