Understanding how aging cells contribute to inflammation and chronic diseases
Mitonuclear signaling pathways in senescence-associated inflammation
This study is looking at how aging cells can cause inflammation and health problems, and it aims to find safer ways to reduce their harmful effects, helping older adults feel better and live healthier lives.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10683280 on NIH RePORTER |
What this research studies
This research investigates the role of aging cells in promoting inflammation and chronic diseases. It focuses on how these senescent cells release harmful substances that can affect overall health. The study aims to explore new methods to reduce the negative effects of these cells without the toxic side effects associated with current treatments. By examining the signaling pathways involved, the research seeks to find safer ways to improve health and longevity in aging individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing chronic inflammation or age-related diseases.
Not a fit: Patients who are not experiencing age-related conditions or chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer treatments that enhance health and longevity by targeting harmful aging cells.
How similar studies have performed: Previous research has shown promise in targeting senescent cells to improve health outcomes, indicating that this approach may be viable.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Miller, Karl Nathan — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Miller, Karl Nathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.