Understanding how aging cells contribute to health issues
Reverse Engineering of Cell Senescence
This study is looking at how getting rid of old, worn-out cells in the body might help us feel younger and healthier as we age, and it's testing some medications to see if they can help with this process in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11017823 on NIH RePORTER |
What this research studies
This research investigates the role of cellular senescence in aging and its impact on age-related diseases. By studying how the elimination of senescent cells can reverse aging features in mice, the researchers aim to identify potential therapies that could be translated to humans. The approach involves exploring specific drugs, like dasatinib, and understanding the mechanisms behind cell senescence and its various sub-types. This research could lead to new treatments that improve health and longevity by targeting the aging process at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or diseases associated with cellular senescence.
Not a fit: Patients who are not experiencing age-related conditions or are younger adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to therapies that significantly improve health and extend lifespan for aging individuals.
How similar studies have performed: Previous research has shown promising results in reversing aging features in animal models, indicating potential for success in human applications.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Kirschner, Marc Wallace — Harvard Medical School
- Study coordinator: Kirschner, Marc Wallace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.