Understanding how aging cells contribute to Carpal Tunnel Syndrome
Official title: The Role of Cellular Senescence in Carpal Tunnel Syndrome
Funded at Mayo Clinic Rochester · NIH-10996173 · Data updated 2026-11-12
This study is looking at how aging cells might play a part in causing Carpal Tunnel Syndrome, which affects many people, and it aims to find ways to treat this condition by focusing on those aging cells to help improve symptoms for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 10, 2020 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $650,582 |
| NIH project number | 5R01AR076347-05 |
| Project ID | NIH-10996173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Carpal Tunnel Syndrome, particularly those experiencing symptoms related to aging.
✕Less likely to help
Patients who do not have Carpal Tunnel Syndrome or those with acute injuries unrelated to aging may not benefit from this research.
What this research studies
This research investigates the role of cellular senescence, or the aging of cells, in the development of Carpal Tunnel Syndrome (CTS), a common condition affecting millions of Americans. The study aims to understand how the accumulation of senescent cells in the connective tissue around the median nerve contributes to the fibrosis and symptoms associated with CTS. By examining tissue samples from CTS patients, researchers will explore the mechanisms behind this condition and test potential treatments that target these aging cells to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate the symptoms of Carpal Tunnel Syndrome and improve the quality of life for affected patients.
How similar studies have gone: Previous research has shown promise in targeting cellular senescence for various age-related conditions, suggesting that this approach may be effective for Carpal Tunnel Syndrome as well.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Gingery, Anne — Mayo Clinic Rochester
- Study coordinator: Gingery, Anne
Related research
Other NIH-funded projects on the same topics.
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How aged cells contribute to carpal tunnel syndrome
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In this trial, people with carpal tunnel syndrome are randomly assigned to either standard carpal tunnel surgery or a pretend surgery to see if relief comes from the operation itself or from placebo effects.
-
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This trial will test whether high-intensity laser therapy helps adults 18–65 with mild-to-moderate carpal tunnel syndrome reduce pain and improve nerve function and hand strength compared with a sham procedure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.