Understanding how aging cells contribute to Alzheimer's disease progression
Senescence-Induced Progression of Alzheimer's Disease
This study is looking at how aging cells that don't work well anymore might affect the worsening of Alzheimer's disease, with the hope of finding new ways to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10849872 on NIH RePORTER |
What this research studies
This research investigates the role of senescent cells, which are aging cells that no longer function properly, in the progression of Alzheimer's disease (AD). The team aims to understand how these cells contribute to cognitive decline and other symptoms associated with AD. By studying brain samples from patients and using animal models, the researchers will explore the mechanisms by which oxidative stress leads to the accumulation of these senescent cells. The ultimate goal is to identify potential therapeutic strategies that could improve outcomes for individuals with Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to age or genetic factors.
Not a fit: Patients with early-stage cognitive impairment not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in animal models regarding the removal of senescent cells and its effects on cognitive decline, indicating potential for success in this approach.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Wang, Gavin Yong — Medical University of South Carolina
- Study coordinator: Wang, Gavin Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.