Understanding how aging cells affect immune responses after infection or vaccination
Official title: Single Cell Analysis Core
Funded at University of Minnesota · NIH-11053490 · Data updated 2026-11-12
This study is looking at how aging cells affect immune cells in your body, especially after you get vaccinated or become infected, to help improve vaccines and treatments for age-related immune issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | March 11, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $451,223 |
| NIH project number | 5P01AI172501-02 |
| Project ID | NIH-11053490 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include older adults and individuals with age-related immune issues.
✕Less likely to help
Patients who are not experiencing age-related immune dysfunction or are younger adults may not receive direct benefits from this research.
What this research studies
This research investigates the role of cellular senescence in influencing the behavior and characteristics of immune cells in various tissues, particularly after infection or vaccination. By utilizing advanced techniques such as single-cell RNA sequencing and spatial transcriptomics, the project aims to provide a detailed understanding of how aging cells impact immune function. Patients may benefit from insights gained through this research, which could lead to improved vaccination strategies and therapies targeting aging-related immune dysfunction. The research will also involve bioinformatics analyses to interpret complex data and develop a comprehensive database for sharing findings.
Why it matters
Potential benefit: If successful, this research could lead to better vaccination strategies and treatments for age-related immune dysfunction.
How similar studies have gone: Other research has shown promise in using single-cell analysis to understand immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Dong, Xiao — University of Minnesota
- Study coordinator: Dong, Xiao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.