Understanding how aging cells affect cancer treatment with radiation.
Investigating the contribution of cellular senescence to the efficacy of radiation therapy.
['FUNDING_CAREER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10911843
This study is looking at how aging cells in tumors affect the success of radiation therapy for people with rectal cancer, hoping to find ways to boost treatment by using the body's immune system alongside radiation.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10911843 on ClinicalTrials.gov |
What this research studies
This research investigates how cellular senescence, a process where cells stop dividing due to damage, influences the effectiveness of radiation therapy in cancer treatment. By examining both mouse and human tumor samples, the study aims to uncover how the secretions from these aging cells can impact the tumor environment and immune response. The research focuses particularly on patients with rectal cancer, exploring how radiation therapy combined with immune treatments may enhance anti-tumor effects. The findings could provide insights into improving cancer therapies by leveraging the body's immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with rectal cancer who are undergoing radiation therapy.
Not a fit: Patients with cancers that do not involve radiation therapy or those with significant immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that utilize the body's immune system to enhance the effects of radiation therapy.
How similar studies have performed: Previous research has shown promising results in understanding the immune-modulatory effects of cellular senescence in cancer therapy, suggesting that this approach may yield significant insights.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROMESSER, PAUL BERNARD — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: ROMESSER, PAUL BERNARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Model, Cancer Patient, Cancer Treatment, CancerModel