Understanding how aging bones affect multiple myeloma and treatment responses
An integrated mathematical modeling approach to define how the aging bone ecosystem drives multiple myeloma evolution and treatment response
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-11049578
This study is looking at how aging bones affect multiple myeloma, a type of blood cancer, to help improve treatments and outcomes for patients like you by understanding how your age and bone health play a role in your care.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11049578 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the aging bone ecosystem and the evolution of multiple myeloma, a type of cancer that affects plasma cells in the bone. By using advanced mathematical modeling and experimental data, the study aims to understand how different clones of cancer cells interact with the aging bone environment and how this affects treatment outcomes. The research will explore the effectiveness of current therapies and develop new adaptive treatment strategies to improve patient responses and delay relapses. Patients may benefit from insights gained about how their age and bone health influence their cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65-74, who are diagnosed with multiple myeloma.
Not a fit: Patients with multiple myeloma who are younger than 65 or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for multiple myeloma patients, potentially enhancing their outcomes and prolonging remission periods.
How similar studies have performed: Previous research has shown promising results in understanding cancer interactions with the bone environment, suggesting that this approach could yield valuable insights.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LYNCH, CONOR C — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: LYNCH, CONOR C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.