Understanding how aging bones affect multiple myeloma and treatment responses
Official title: An integrated mathematical modeling approach to define how the aging bone ecosystem drives multiple myeloma evolution and treatment response
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11049578 · Data updated 2026-11-12
This study is looking at how aging bones affect multiple myeloma, a type of blood cancer, to help improve treatments and outcomes for patients like you by understanding how your age and bone health play a role in your care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $620,521 |
| NIH project number | 1R01CA290007-01A1 |
| Project ID | NIH-11049578 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65-74, who are diagnosed with multiple myeloma.
✕Less likely to help
Patients with multiple myeloma who are younger than 65 or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the relationship between the aging bone ecosystem and the evolution of multiple myeloma, a type of cancer that affects plasma cells in the bone. By using advanced mathematical modeling and experimental data, the study aims to understand how different clones of cancer cells interact with the aging bone environment and how this affects treatment outcomes. The research will explore the effectiveness of current therapies and develop new adaptive treatment strategies to improve patient responses and delay relapses. Patients may benefit from insights gained about how their age and bone health influence their cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for multiple myeloma patients, potentially enhancing their outcomes and prolonging remission periods.
How similar studies have gone: Previous research has shown promising results in understanding cancer interactions with the bone environment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Lynch, Conor C — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Lynch, Conor C
Related research
Other NIH-funded projects on the same topics.
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How aging bones help myeloma grow and resist treatment
Researchers are combining lab experiments, aging mouse models, and computer-based models to map how changes in the aging bone environment let multiple myeloma cells survive treatment in older adults.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
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Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
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How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
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Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
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BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.